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Povišena je koncentracija diazepama u plazmi usled inhibicije CYP3A4 metaboli?kog puta. U studiji kod zdravih dobrovoljaca primena 200 mg itrakonazola dnevno tokom four dana pove?ala je PIK pojedina?ne oralne doze od 5 mg diazepama za oko 15%, ali ova interakcija nije bila od klini?kog zna?aja, što je potvr?eno psihomotornim testovima. Mogu?e je

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